Synthetic lethals in HIV: ways to avoid drug resistance
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چکیده
منابع مشابه
Synthetic lethals in HIV: ways to avoid drug resistance: Running title: Preventing HIV resistance
Background: RNA viruses rapidly accumulate genetic variation, which can give rise to synthetic lethal (SL) and deleterious (SD) mutations. Synthetic lethal mutations (non-lethal when alone but lethal when combined in one genome) have been studied to develop cancer therapies. This principle can also be used against fast-evolving RNA-viruses. Indeed, targeting protein sites involved in SD + SL in...
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Synthetic lethals are variants at different loci that have little or no effect on viability singly but cause lethality in combination. The importance of synthetic lethals and, more generally, of synthetic deleterious loci (SDL) has been controversial. Here, we derive the expected frequencies for SDL under a mutation-selection balance for the complete haploid model and selected cases of the dipl...
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ژورنال
عنوان ژورنال: Biology Direct
سال: 2015
ISSN: 1745-6150
DOI: 10.1186/s13062-015-0044-y